NU PAWS
with CURCUMIN BIOBDMC™ 

Not all Curcumin is created equal...​

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As part of his work, Franco mapped the pharmacology of Curcumin and he discovered something amazing…

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Curcumin, is the active ingredient in turmeric, a popular spice that gives curry its distinctive color. Turmeric has been used for centuries in Ayurvedic and Chinese medicine as an anti-inflammatory.

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Franco knew that Curcumin is really comprised of three different curcuminoids:

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• Curcumin I (diferuloylmethane),

• Curcumin II (desmethoxycurcumin), and

• Curcumin III (bis-desmethoxycurcumin).

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Historically, scientists believed they all performed similarly in the body but he believed that while they did in fact have similar features conveying similar pharmacological activity they had different molecular features that could also impart unique pharmacological activity for each.  The unfortunate challenge is that an extraction today using plants from one part of the world grown under different environmental conditions will produce a proportion of these curcuminoids that is different from a Curcumin or turmeric plant collected from another harvest.  Since Franco's research demonstrates a differential activity for each this would change the  effect of the extract from batch to batch and consumer expectations and experience would also be very different.  

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A product you buy today claiming a 95% Curcumin purity could be very different from another you buy next month while displaying the same 95% standardization due to fluctuations in this curcuminoid proportion within the 95% yield.  It's no wonder why it works one way one time... and may not feel like it works well or the same way the next time you buy it.  Franco demanded that reliability and repeatability of results MUST be standardized and so his quest to do so for everyone using Curcumin was set in motion.

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The Curcumin supplements you buy now are mostly comprised of Curcumin I (70-80%) and Curcumin II (12-20%). But they have only tiny amounts of Curcumin III (0.5% to 1.5%).

 

When Franco mapped the pharmacology of Curcumin for his research, he found that these Curcumin compounds fight inflammation in different ways. Curcumins I and II inhibit a key trigger for inflammation called NF-kappaB. They inhibit this protein to relieve pain and inflammation. Dozens of studies show that ordinary Curcumin can inhibit inflammatory proteins such as NF-kB and C-reactive protein (CRP), along with enzymes such as COX and LOX.

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But Franco discovered that Curcumin III neutralizes an entirely different inflammatory protein called MSK1. And this protein is responsible for triggering pain and inflammation at the genetic level — before NF-kB becomes a factor.

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In other words, Curcumin III does what the other Curcumins do — dampening NF-kB. But it has a “superpower.” It also neutralizes MSK1 — to give you an extra pain-relieving boost!

The Curcumin supplements you see on the market however, have practically NO Curcumin III in them!

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So Franco set out to change that…

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Curcumin displays strong anti-inflammatory potential in the entire body, and in the near future it will be recognized as one of the vital anti-aging nutrients. It plays a core role in any health program.

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Curcuminoids, extracted from turmeric, contribute a potent defense of DNA. Studies have compared its anti-inflammatory potential and anti-cancer properties against common pharmaceutical therapies to reveal, in some cases, better results and in other cases conclusive synergistic value. Other pharmaceutical companies have not reported on this. The incredible facts rising out of this research reveal that Curcumin, unlike a common non-steroidal anti-inflammatory drug (NSAID), doesn’t induce gastrointestinal, liver, and/or kidney toxicity.

 

Having read reports of the potential of Curcuminoids to down-regulate

cyclo-oxygenase-enzyme activity and eicosanoid-hormone biosynthesis, he was confident some time ago that they regulated gene expression of the enzymes involved in eicosanoid-hormone production, much like the protective NF-kappa-B gene influence of alpha lipoic acid. In this way Curcuminoids prevent the over-expression of genes involved in the immune and inflammatory response.

 

After ongoing, relentless search, he found his answer. Curcumin had been investigated for its ability to suppress the activation of HIV to the status of AIDS. In a 1993 Harvard University study it was demonstrated that Curcumin inhibited the expression of a gene in the DNA of the virus. This gene was responsible for turning on HIV to initiate the assault on the body. Recently, through this historical work, Curcumin has been shown to block the activation of NF-kappa-B. Not only is Curcumin a powerful HIV inhibitor, it can be justifiably applied as part of the anti-aging and anti-inflammatory program with scientific proof that it works powerfully alongside or independent of alpha lipoic acid.  This insight, was the impetus for his push to study curcuminoids exclusively and define with more accuracy how they can be used and even engineered to increase their potential to bring general health benefits and disease treatment.